{"id":41,"date":"2020-02-01T17:10:44","date_gmt":"2020-02-01T09:10:44","guid":{"rendered":"https:\/\/167.179.74.142\/?page_id=41"},"modified":"2020-02-01T17:15:24","modified_gmt":"2020-02-01T09:15:24","slug":"elementor-41","status":"publish","type":"page","link":"https:\/\/www.swissnmn.com\/?page_id=41","title":{"rendered":"SwissNMN Facts"},"content":{"rendered":"\t\t
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GeneUltra SwissNMN has been carefully formulated according to years of research on longevity and aging. The main ingredient in SwissNMN is Nicotinamide Mononucleotide (NMN), 99.95% pure, the best in class. NMN is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme which is involved in thousands of cellular processes. Research has shown that NAD+ decreases with age and this decrease is involved in age related pathology and various diseases.
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\"NAD+<\/div>\n

NAD+ Levels decline with age<\/h2>\n

Studies have shown that NAD+ levels decrease with age. Studies in both mouse models and human subjects have demonstrated age-related decreases in circulating NAD+. NAD+ is involved in many cellular processes, including fatty acid oxidation, insulin secretion and lipid metabolism. Dysfunctions in these and other NAD+ dependent cellular functions are associated with frailty and pathophysiologies which become more common with advanced age.<\/p>\n

\"NAD+\"NAD+<\/div>\n<\/div>\n<\/div>\n
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The observed correlation between NAD+ levels and aging adds weight to the idea that NAD+ may play a role in cell senescence and longevity.<\/h2>\n<\/div>\n<\/div>\n<\/div>\n
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NAD+ Precursor Supplementation Increases Lifespan in Mouse Models<\/h2>\n

Studies in mouse models have shown that supplementation with NMN can increase lifespan, decrease and age-related frailty. This is likely due to NAD+ being a coenzyme for the sirtuin family of proteins, which can activate cellular repair pathways and which have shown to be involved in increasing lifespan and healthspan.<\/p>\n

\u201cThe observed correlation between NAD+ levels and aging adds weight to the idea that NAD+ may play a role in cell senescence and longevity\u201d<\/p>\n

\u201cMaintenance of intracellular NAD+ may therefore be beneficial in counteracting at least some of the age-related cellular degenerative processes.\u201d<\/p>\n

\"supplementation<\/div>\n

NMN Supplementation and Type 2 Diabetic mice<\/h2>\n

Supplementing diabetic mice with NMN was able to ameliorate Type 2 Diabetes-associated pathophysiologies. Mice given NMN displayed increased insulin sensitivity, decreased blood sugar and overall improvements in metabolic health markers.<\/p>\n

\u201cNAD+ biosynthesis is compromised by HFD and aging, contributing to the pathogenesis of type 2 diabetes.\u201d<\/p>\n

\u201cpromoting NAD+ biosynthesis by administering NMN, a key NAD+ intermediate, can be an effective intervention to treat the pathophysiology of diet- and age-induced Type 2 Diabetes. \u201c<\/p>\n

\"NMN\"NMN<\/div>\n

NAD Supplementation and Alzheimer\u2019s mouse models<\/h2>\n

Studies in Alzheimer\u2019s model transgenic mice have shown significant improvement in symptoms with NMN treatment. Mice treated with NMN showed improved memory, cognitive function as well as a decrease in beta-amyloid plaques in brain tissue.<\/p>\n

\u201cThe data prove that NMN treatment greatly reduces multiple Alzheimer\u2019s-disease-associated pathological characteristics,\u201d<\/p>\n

\u201cIn summary, this study provides essential preclinical evidences that NMN takes effects in reversing cognitive deficits and substantially lowering the burden of amyloid plaque, neuroinflammation, cerebral amyloid-\u03b2 concentrations, and loss of synapse in middle-aged ADTg mice.\u201d<\/p>\n

\"data\"NMN<\/div>\n

NMN and Vascular Health in mice<\/h2>\n

Arterial stiffening is associated with advanced age and is a major contributor age-associated heart disease. In addition to being associated with heart problems, stiffening of arteries has been linked to cognitive impairments, metabolic disorders and age-related muscle loss. Treating old mice with NMN significantly improved arterial health and reduced arterial stiffness compared to untreated old mice.<\/p>\n

\u201cThe results of this study provide the first evidence that oral supplementation with NMN represents a novel strategy for combating arterial aging and its pathological sequelae.\u201d<\/p>\n

\"NMN\"NMN<\/div>\n

Ingredients<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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SwissNMN Proprietary Blend<\/h4>\n
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\u03b2-Nicotinamide Mononucleotide 99.95% Pure<\/div>\n
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GeneUltra SwissNMN has been carefully formulated accord… \u9605\u8bfb\u66f4\u591a »SwissNMN Facts<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-templates\/template-pagebuilder-full-width.php","meta":{"neve_meta_sidebar":"full-width","neve_meta_container":"","neve_meta_enable_content_width":"on","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":""},"_links":{"self":[{"href":"https:\/\/www.swissnmn.com\/index.php?rest_route=\/wp\/v2\/pages\/41"}],"collection":[{"href":"https:\/\/www.swissnmn.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.swissnmn.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.swissnmn.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.swissnmn.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=41"}],"version-history":[{"count":4,"href":"https:\/\/www.swissnmn.com\/index.php?rest_route=\/wp\/v2\/pages\/41\/revisions"}],"predecessor-version":[{"id":45,"href":"https:\/\/www.swissnmn.com\/index.php?rest_route=\/wp\/v2\/pages\/41\/revisions\/45"}],"wp:attachment":[{"href":"https:\/\/www.swissnmn.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=41"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}